Q1: While I'm am not a total newbie to vaping this is my first VV device and my first set of Clearos so I was wondering if there are any caveats that I need to be aware that users have stumbled across?
Whether you have the 2.4-2-6ohm CE2's or the 2.6-2.8ohm ones doesnt make to much of a difference on the voltage setting..... they can take the higher voltages even though at standard voltages they give a solid throat hit. Like any atomiser though running them at higher voltages will stress the coil....... after a little while dropping the voltage down to 3.7v they will seem weak.
Q2: If I used a blend of PG/VG say 60/40 will I need to do anything special to the wicks so they pick up better?
They will wick fine with that mix. If you do get some burnt tastes and poor wicking you can mod them with the parts included with the package. There is thread here that may be of some help. http://www.totallywicked-eliquid.com/forum/cartomisers-95/510-ce2-xl-how-long-do-they-last/msg246871/#msg246871
Q3: Some reviews I've seen mention taking the Clearo apart and burning the wick material until it turns white again to get rid of a "plastic" taste in the vapor; as these were early reviews of the product is this still necessary?
I have never tried this method but from what I am told it does work.... Some just crank up the voltage when they fade..... including me.... I toss them after a week though.... I like that fresh atty vape.